Proven Solutions ImprovedSM
Tosk is a dynamic drug development company dedicated to alleviating the painful, debilitating, and potentially fatal side effects of front line cancer therapies and to make certain cancer drugs effective in patients who do not currently benefit from treatment. We are developing a family of what we call CompanionTM drugs that, when administered alongside certain cancer therapies, such as methotrexate, doxorubicin, cisplatin, EGFR inhibitors, and radiation — what we call parent therapies — will significantly improve patient outcomes. In other words, "PROVEN SOLUTIONS IMPROVEDTM ".
Tosk has patented two new pharmaceutical products and has two other preclinical-stage products in development.
TK-90: Our most advanced, patented drug — now in human clinical trials — is targeted at mucositis side effect reduction. Mucositis is the painful inflammation and ulceration of the mucous membranes lining the mouth, throat, and digestive tract, usually as an adverse effect of chemotherapy or radiation. Mucositis can occur anywhere along the gastrointestinal tract, including the stomach, intestines, and anus. Oral mucositis, inflammation and ulceration that occurs in the mouth, is a common and often debilitating complication of cancer treatment. Mucositis in the gut can introduce a route of infection that can be debilitating and potentially fatal.
There were 1.7 million new cases of cancer and 600,000 cancer-related deaths in the U. S. last year. This is despite regular media reports of breakthroughs in treatment, such as monoclonal antibodies and immunotherapies, and many billions of dollars spent on cancer research. New approaches may have long-term promise, but the reality is, most cancers are still treated with drugs that are decades old.
Tosk uses two proprietary drug discovery methods to identify potential CompanionTM drugs. Together, we call these methods OMDSM for Optimizing Marketed DrugsSM because they allow us to efficiently screen compounds for their potential to block the adverse side effects of prescription drugs, or make certain drugs effective in patients who currently do not benefit from therapy.